Comparison of potency of some nicotinic blockers on nicotinic receptor and Ca-activated K (Ca-K) channels in rat superior cervical ganglicn (SOG)
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منابع مشابه
Age-associated endothelial dysfunction in rat mesenteric arteries: roles of calcium-activated K(+) channels (K(ca)).
Age-associated changes in large blood vessels were characterized by increased arterial wall thickness, luminal dilation and impaired endothelial function. But little is known about the effect of age on structural and functional changes in small resistance arteries. The mechanisms underlying age-associated endothelial dysfunction in rat mesenteric resistance arteries were investigated in the pre...
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Masafumi Kita, Takakazu Yunoki, Koichi Takimoto, Minoru Miyazato, Kaori Kita, William C. de Groat, Hidehiro Kakizaki, and Naoki Yoshimura Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Urology, Asahikawa Medical College, Asahikawa, Japan; Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of ...
متن کاملCa(2+)-activated K+ channels in human leukemic T cells
Using the patch-clamp technique, we have identified two types of Ca(2+)-activated K+ (K(Ca)) channels in the human leukemic T cell line. Jurkat. Substances that elevate the intracellular Ca2+ concentration ([Ca2+]i), such as ionomycin or the mitogenic lectin phytohemagglutinin (PHA), as well as whole-cell dialysis with pipette solutions containing elevated [Ca2+]i, activate a voltage-independen...
متن کاملSmall-conductance Ca(2+)-activated K(+) channels: Heterogeneous affinity in rat brain structures and cognitive modulation by specific blockers.
Small-conductance calcium-activated potassium channels (K(Ca)2) generating the medium afterhyperpolarization seen after an action potential modulate the neuronal integration signal. The effects of two K(Ca)2 channel blockers, apamin, specific to K(Ca)2.2 and K(Ca)2.3 channels, and lei-Dab7, which binds to K(Ca)2.2 channels only, were compared to evaluate the involvement of K(Ca)2 channel subuni...
متن کاملExpression of Ca-activated K Channels and Their Role in Proliferation of Rat Cardiac Fibroblasts.
Cardiac fibroblasts constitute one of the largest cell populations in the heart, and contribute to structural, biochemical, mechanical and electrical properties of the myocardium. Nonetheless, their cardiac functions, especially electrophysiological properties, have often been disregarded in studies. Ca(2+)-activated K(+) (K(Ca)) channels can control Ca(2+) influx as well as a number of Ca(2+)-...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1987
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)58432-3